Consultant histopathologist, department of histopathology, university of benin. A separate code of practice for gynaecological cytopathology is in preparation. With contributions from experts in the field internationally and many new colour images atlas of fine needle aspiration cytology, second edition provides a comprehensive and uptodate guide to fnac for pathologists, cytopathologists, radiologists, oncologists, surgeons and others involved in the diagnosis and treatment of patients with. Although fna cytology has been shown to be a costeffective, reliable. Fine needle aspiration biopsy is a clinical technique used to obtain cells, tissue, andor fluid through a thin needle for the purpose of diagnosis and manage. Patients and methods this is a retrospective study of 296 diagnosed cases of thyroid nodules referred to cytology unit, pathology department, nci, who underwent fnac for diagnosis. A fine needle biopsy is a quick and effective test for determining the status of suspect tissue.
Benefits and risks of a fine needle aspiration biopsy. Fine needle aspiration cytology of palpable biopsia incisional y excisional lesions. Proper aspiration technique and subsequent sample submission with appropriate and immediate fixation are crucial for optimal case assessment and outcome. The study also evaluated the predictive value of preoperative fine needle aspiration cytology fnac in surgical decision making, by comparing the final pathological diagnosis with the initial fnac result. Value and limitations of cytologic criteria for the diagnosis of hepatocellular carcinoma by fine needle aspiration biopsy. Fine needle aspiration cytology of an unusual case of papillary thyroid carcinoma metastatic to the breast sharda lallu, sarla naran and catherine koleda anatomic pathology, wellington scl, wellington introduction papillary carcinoma of the thyroid is the most common form of thyroid malignancy, generally carries a good prognosis and. Fineneedle aspiration definition, purpose, procedure. Fine needle aspiration cytology of myxoid lesions of soft tissues. Fnab and the science of cytopathology in the comprehensive clinical manage ment of patients presenting with various tumors. Syed furqan hasan department of pathology national institute of child health karachi. Orell and sterretts fine needle aspiration cytology. Development and application of specimen collection techniques in.
Fine needle aspiration fna entails using a narrow gauge 2522g needle to collect a sample of a lesion for microscopic examination. A nondiagnostic fna is problematic for the clinician and patient because it can result in repeated procedures, multiple physician visits, and a delay in definitive treatment. For fine needle aspiration specimens the following specimen collection and sample preparation guidelines are recommended. School of tropical medicine, kolkata fnac sample of cells aspirated from suspicious mass for diagnostic purposematerial converted to cytological sample for microscopic examination. Predictors of nondiagnostic cytology in surgeonperformed. Fineneedle aspiration purpose a fineneedle aspiration is a type of needle biopsy thats done in order to rule out or detect the development of. Use of fine needle aspiration cytology fnac in human medicine stems from the nineteenth century. It allows a minimally invasive, rapid diagnosis of tissue but does not preserve its histological architecture. Fine needle aspiration cytology versus frozen section in. The forms are pdf files which can be filled in on the computer and then printed. Fineneedle aspiration cytology of pleomorphic lobular. A comparison of the use of the trucut needle and fine needle aspiration cytology in the preoperative diagnosis of carcinoma of the breast. Rj zarbo, cm fenogliopreiserinterinstitutional database for comparison of performance in lung fine needle aspiration cytology arch pathol lab med, 116 1992, pp.
These samples are then used for microscopic examination. Fine needle aspiration cytology, with immediate reporting. The objective of this study was to determine the efficacy of fine needle aspiration cytology in diagnosis and management of thyroid nodules. Fine needle aspiration fna cytology is an accepted. Article pdf available in annals of the royal college of surgeons of england 895. Obtaining an adequate specimen requires attention to good aspiration technique as well as to processing of material obtained. Few statistically based criteria for the adequacy of breast fine. Liquid based cytology of cell remnants in needles used for. Preparation of the site for aspiration if microbiological tests are to be performed on. Endoscopic ultrasonography, fineneedle aspiration biopsy. Google scholar silverman jf, gurley am, harris jp, weaver md, bernacki eg. Predictive factors for biopsia incisional y excisional cancer in patients diagnosed atypical ductal hyperplasia at core needle biopsy.
Fine needle aspiration fna cytopathology of the breast is an effective means of distinguishing malignant from benign, however. Breast fine needle aspiration cytology and core biopsy a guide for practice intended to assist all clinicians involved in the investigation of women with breast symptoms or imagedetected breast lesions, primarily pathologists, surgeons and radiologists. Procedure for fine needle aspiration cytology materials required. Breast fine needle aspiration cytology and core biopsy. Fineneedle aspiration fna is a valuable investigative tool for the workup of breast masses. The utility of fine needle aspiration cytology in canine lymphadenopaties article pdf available in annals of the romanian society for cell biology 192. Pdf the utility of fine needle aspiration cytology in. Fine needle aspiration cytology is an inexpensive, atraumatic technique for the diagnosis of disease sites. Sole m calvet x cuberes t maderuelo f bruix j bru c et al. Two patients who did not undergo intraoperative frozen section examination were either over or undertreated, which is discussed. This paper describes the technique and illustrates how it may be applied to the management of tumours throughout the body. Fineneedle aspiration cytology in tumour diagnosis.
Diagnostic utility of fine needle aspiration cytology in. Fine needle aspiration cytology fnac entails using a narrow gauge needle to collect a sample of a lesion for microscopic examination. Fine needle aspiration cytology in the diagnosis of canine. A useful diagnostic tool in childhood tumors introduction.
Tucson pathology associates has board certified pathologists with specialties in anatomic and clinical pathology, cytopathology, hematopathology and dermatopathology. Cytologyfine needle aspiration requisition department of surgical pathology, 801 s. Fine needle aspiration cytology began to flourish in the 1950s and 1960s in europe. Pdf fineneedle aspiration cytology of the breast researchgate. Principles and techniques of biopsy with special reference to fine. Fine needle aspiration cytology is a reliable method that has high sensitivity to distinguish between benign and malign salivary gland lesions. Pdf fineneedle aspiration cytology fnac is an established, highly accurate, and costeffective method for diagnosing lesions in different organs. In case of suspicious fnac reports, reliability and. Liquid based cytology, needle cell remnants, fine needle aspiration, breast 1.
Fine needle aspiration specimens fine needle aspiration of mass lesions is commonly utilized in the detection and characterization of a variety of malignant diseases. Usefulness of rapid onsite evaluation specimens from. Fine needle aspiration biopsy for cytological examination fnac is becoming increasingly accepted as a means of tissue diagnosis in breast disease. Fine needle aspiration fna cytology is a diagnostic procedure. A volume in foundations in diagnostic pathology, 1e. Fineneedle aspiration fna is a diagnostic procedure used to investigate lumps or masses. Role of fine needle aspiration cytology in the diagnosis.
Coreneedle biopsy and fineneedle aspiration cytology are compared in depth, with attention to their relative strengths and weaknesses and indications. Pdf analysis of fineneedle aspiration cytology of the. Fine needle aspiration fna cytology cellular pathology. Stanford libraries official online search tool for books, media, journals, databases, government documents and more. Fine needle aspiration cytology fnac is a procedure to perform medical diagnosis on masses, tissues and lumps. Diagnosis of hepatocellular carcinoma by fine needle aspiration cytology. Tamal kanti ghosh md medical superintendent cum vice principal. In addition, the impact of molecular classification of breast cancers on cytologic diagnosis is explored, and the use of molecular techniques in diagnostic cytology is discussed. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. In recent years fine needle aspiration cytology fnac has been a tool for probable diagnosis because it is speedy, rapid, cost effective and less invasive procedure in comparison to biopsy. It allows a minimally invasive, rapid diagnosis of tissue but does not preserve histological architecture. Fineneedle aspiration cytology in the diagnosis of primary breast.
Breast fine needle aspiration cytology and core biopsy a. Needle 2225 guage, disposable syringe 3 20 ml, new glass slides, spirit swab, and suitable fixative is required. Case study fine needle aspiration cytology of an unusual. Agarwal p, toi pc, subramaniam h, apoorva lakshmi s. Get a printable copy pdf file of the complete article 3. At surgery, lymph nodes were dissected and categorized by location and underwent histopathologic evaluation. Diagnostic utility of fine needle aspiration cytology in superficial l. Evaluation of accuracy of fine needle aspiration cytology fnac in the diagnosis of different thyroid lesions. Diagnostic accuracy of fine needle aspiration cytology in. Fine needle aspiration cytology fnac is an established costeffective diagnostic tool for skeletal lesions. Currently fnac has been widely employed in the diagnosis of lesions from various origins, but mainly in cancer 1. Preparation of the site for aspiration if microbiological tests are to be performed on a portion of sample collected, or a body cavity is to. Pathology outlines general step by step fna procedure.
Fineneedle aspiration definition fineneedle aspiration, as opposed to coreneedle biopsy, is a type of biopsy wherein instead of taking a sample of the solid matter of a certain organ, it instead takes the liquid or fluid portion of the same organ. Samples are usually collected using thin hollow needles of about 2325 gauge. Fine needle aspiration cytology of the breast springerlink. Fine needle aspiration cytology shows up a wellformed epithelioid granuloma and the linfasenitis of caseous necrosis 36. The diagnostic role of fnac in cysticercosis was first emphasized by kung et al. Fine needle aspiration cytology of cysticercosisa case report. Each single needle pass should take less than 5 10 seconds to complete, with 10 20 excursions back and forth cutting motions of the needle into the target being performed during this time when sampling vascular targets or the thyroid gland, single pass should take 2 5 seconds and use smaller gauge needles e. Presentations ppt, key, pdf logging in or signing up. To open these files you will need adobe reader on your computer. However, combining fnac resulted in a better preoperative diagnosis rate. Fine needle aspiration fna is the standard of care for the diagnostic workup of thyroid nodules but despite its proven utility, the nondiagnostic rate for thyroid fna ranges from 636%.
Use of fine needle aspiration cytology with immediate reporting in. One hundred and fifty one new patients attending a breast clinic over a 6 month period underwent fine needle aspiration cytology fnac, with immediate reporting of the smears in the clinic. The sensitivity of fine needle aspiration cytology and frozen section for detecting branchial cleft cysts was 75 per cent and 100 per cent respectively. Fine needle aspiration cytology fnac is a wellrecognized diagnostic procedure for the evaluation of inflammatory nodules caused by parasites. Fine needle aspiration cytology fnac as a diagnostic. The overall cytological features of chondroblastoma are very much characteristic which helps in diagnosing this tumour with a high degree of precision on fine needle aspiration fna. Fine needle aspiration biopsy fnab in the diagnosis of. Spitz dj, reddy v, selvaggi sm, kluskens l, green l, gattuso p. Endoscopic ultrasonographyguided fineneedle aspiration biopsy was done on suspicious contralateral posterior mediastinal or subcarinal lymph nodes identified by ultrasonography.
Prospective comparison of cytological specimen adequacy assessment by different rapid staining techniques for rapid onsite evaluation in fine needle aspiration cytology and their costeffectiveness. Inceptionism and residualism in the classification of. Compared to a surgical biopsy, fine needle aspiration biopsy involves little possibility of scarring, infection or pain, and has a significantly shorter recovery time. Introduction liquidbased cytology is a technique that enables cells to be suspended in a monolayer and thus making better morphological assessment possible with improved sensitivity and specificity because fixation is better and nuclear details. Fineneedle aspiration fna cytology is an inexpensive, effective and. Fine needle aspiration fna cytology principle of examination. Fine needle aspiration fna biopsy information myvmc. Role of fineneedle aspiration cytology and core biopsy in the. In fine needle aspiration, a thin needle is inserted into an area of abnormalappearing tissue or body fluid. Bscc code of practice fine needle aspiration cytology. The simplicity of aspiration technique, however, does not mean that interpretation is less demanding than that of the surgical biopsy specimen.
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